Regulation of filtration rate a. Glomerular filtration rate (GFR) remains relatively constant, but may increase or decrease as required. b. Increased activity of the sympathetic nervous system can maintain blood

Regulation of filtration rate a. Glomerular filtration rate (GFR) remains relatively constant, but may increase or decrease as required. b. Increased activity of the sympathetic nervous system can maintain blood pressure with minimal change in GFR. c. When the macula densa senses decreased amounts of chloride, potassium, and sodium ions in the last part of the ascending limb of the nephron loop, it causes juxtaglomerular cells to release renin. d. Renin release triggers a series of changes leading to vasoconstriction of afferent and efferent arterioles, which minimizes any decrease in glomerular filtration rate, and also stimulates aldosterone secretion,which stimulates tubular sodium reabsorption.

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