Transcribed Image Text: 6. You are interested in how the density of NMDA receptors in the postsynaptic membrane prior to stimulation will affect future LTP and LTD production. You prepare

Transcribed Image Text: 6. You are interested in how the density of NMDA receptors in the postsynaptic membrane prior to
stimulation will affect future LTP and LTD production. You prepare mouse hippocampal slices with three
types of postsynaptic neurons – neurons that have either very high densities, very low densities, or zero
density of NMDA receptors. You stimulate the neurons presynaptic to these different types of
postsynaptic neurons using a brief, high-frequency stimulation protocol (100 Hz) or a prolonged,
low-frequency stimulation protocol (10 Hz). You then record whether an LTP or LTD was produced. Match
the different NMDA receptor densities in the first column with the expected LTP/LTD occurrences in the
second column of the table below:
NMDA Receptor/Channel Density Before
Results
Stimulation
1. Very high
A. No LTP during brief, high-frequency
stimulation.
No LTD during prolonged, low-
frequency stimulation.
2. No NMDA receptors
B. No LTP during brief, high-frequency
stimulation.
LTD during brief, high-frequency
stimulation.
3. Very low
C. No LTD during prolonged, low-
frequency stimulation.
LTP during prolonged, low-frequency
stimulation.

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