According to the “Hawaiian Punch” principle, different compartments of the secretory and endocytic pathways are topologically equivalent to each other and to the extracellular space. Explain how vesicular transport generates

According to the “Hawaiian Punch” principle, different compartments of the secretory and endocytic pathways are topologically equivalent to each other and to the extracellular space. Explain how vesicular transport generates this topological equivalence. These compartments are topologically equivalent because molecules can move between them without having to move out of the cell. Transport vesicles cause this “topological equivalence” because they are responsible for the actual movement of the molecules mentioned above. They break off from one compartment, carrying the necessary molecules, and then fuse to its targeted compartment; thus, making the compartments topologically equivalent. During mitosis in mammalian cells, the nuclear envelope breaks down into vesicles. Are the topological properties of the cell altered by this event? Justify your answer.

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