For this discussion post: •Describe the rationale for a step in the research and development of a new drug that does apply to your practice. I work in pediatric (children) nursing. I dont have any in particular, so research a new drug and the steps in takes for researching and developing a new drug. Needs to be 150 words with at least one APA formatted reference throughout the post, and at the end of the post in the reference section.
The research and development (R&D) of new drugs plays a crucial role in advancing healthcare and improving patient outcomes. In the field of pediatric nursing, the development of new drugs is vital for addressing the unique healthcare needs of children. One particular step in the R&D process that is relevant to pediatric nursing is preclinical research.
Preclinical research involves conducting experiments on animals, such as rats or mice, to assess the safety and effectiveness of a potential drug before testing it in humans. This step ensures that any potential risks or harmful effects are identified early on, minimizing the chances of adverse reactions when the drug is eventually administered to pediatric patients.
During preclinical research, scientists conduct extensive laboratory experiments to understand how the drug interacts with the body and if it produces the intended therapeutic effects. This includes studying the drug’s pharmacokinetics (how the body absorbs, distributes, metabolizes, and eliminates the drug) and pharmacodynamics (the drug’s effects on the body). By studying these properties, researchers can determine appropriate dosing regimens and predict the drug’s potential efficacy in treating specific conditions.
Animal models are carefully selected to mimic the physiology of pediatric patients as closely as possible. However, it is important to note that the responses observed in animals may not always directly translate to the response in humans. Despite this limitation, preclinical research provides crucial insights into the drug’s safety profile and aids in the design of subsequent clinical trials.
Additionally, preclinical research also helps to identify any potential toxicity or adverse effects of the drug. For example, certain drugs may have teratogenic effects, causing harm to the developing fetus during pregnancy. By conducting preclinical studies, researchers can identify these risks early on and make informed decisions regarding the drug’s development and potential use in pregnant women or women of childbearing age.
One example of a new drug that has undergone preclinical research in the pediatric nursing field is palivizumab, commonly known as Synagis. Synagis is an antibody medication used to prevent severe respiratory syncytial virus (RSV) infection in high-risk infants and children. The drug was extensively evaluated in preclinical studies to assess its safety and efficacy before proceeding to clinical trials.
In conclusion, preclinical research is a crucial step in the R&D process of new drugs in pediatric nursing. It provides valuable information about the drug’s pharmacokinetics, pharmacodynamics, safety, and potential adverse effects. By conducting preclinical studies, researchers can make informed decisions regarding the drug’s further development and ensure its safety and efficacy in pediatric patients.